復方六草消痤湯聯合阿達帕林凝膠外用治療丘皰疹型痤瘡的療效探討
發(fā)布時間:2018-06-24 來源: 散文精選 點擊:
[摘要] 目的 觀察復方六草消痤湯聯合阿達帕林凝膠外用治療丘皰疹型痤瘡的臨床療效,探討其作用機理,為其推廣提供理論依據。方法 方便選取長春中醫(yī)藥大學附屬醫(yī)院在2013年6月—2014年5月治療的90例符合標準的痤瘡患者隨機分為兩組,觀察其療效及安全性:治療組采用復方六草消痤湯加減聯合阿達帕林凝膠外用;對照組采用阿達帕林凝膠外搽,觀察2個月后各組療效,比較治療結果。半年后隨訪,復發(fā)情況。結果 2個療程結束后,治療組總有效率100.0%,對照組總有效率73.3%,兩組療效差異有統(tǒng)計學意義(P<0.05),兩組均沒有不良反應發(fā)生。半年后治療組復發(fā)率6.6%,對照組復發(fā)率17.7%。結論 復方六草消痤湯加減聯合阿達帕林凝膠外用治療丘皰疹型痤瘡的臨床療效療效高,安全可靠有顯著優(yōu)勢,值得推廣應用。
[關鍵詞] 丘皰疹型痤瘡;復方消痤湯;辨證論治
[中圖分類號] R4 [文獻標識碼] A [文章編號] 1674-0742(2018)01(c)-0165-03
[Abstract] Objective This paper tries to observe the effect of compound Liucaoxiaocuo Decoction combined with Adapalene Gel treat Papulovesicles type Acne, to explore its action mechanism, to provide theoretical basis for its promotion. Methods 90 patients with acne vulgaris who were treated the affiliated hospital to Changchun University of Chinese Medicine from June 2013 to May 2014 were convenient selected and randomly divided into two groups to observe the efficacy and safety. Treatment group adopted compound Liucaoxiaocuo decoction, Adapalene Gel paint; The control group adopted Adapalene Gel paint; the curative effect was observed after 3 months. The curative effects were compared; 6 months later, the recurrence was followed up. Results After 2 courses, the total effective rate of the treatment group was 100.0%, the other was 73.3%, and the difference was significant(P<0.05), and no adverse reactions occurred. After six months, the recurrence rate of the treatment group was 6.6%, and the control group was 17.7%. Conclusion The clinical curative effect of this therapy is high, safe and reliable. It has obvious advantages and is worthy of popularization and application.
[Key words] Papulovesicles acne; Compound Liucaoxiaocuo decoction; Treatment based on syndrome differentiation
痤瘡是一種皮膚毛囊和皮脂腺慢性炎癥,是皮膚科的常見病。好發(fā)于面部和胸背部,可表現為粉刺,丘疹,膿皰,結節(jié),囊腫,及疤痕等皮損,不僅會影響患者的美貌,還會增加心理和情緒負擔。祖國醫(yī)學對痤瘡的治療積累了豐富的經驗,強燕等[1]報道了痤瘡的中西醫(yī)研究進展。張秋仔[2]從五臟辯治痤瘡,該院在臨床實踐中發(fā)現,痤瘡患者中以丘皰疹型為多,遵從周星[3]從肺論治理念,該研究2013年6月—2014年5月以復方六草消痤湯加減聯合阿達帕林凝膠外用治療丘皰疹型痤瘡45例,取得明顯療效。現報道如下。
1 資料與方法
1.1 一般資料
病例來源于方便選取該院治療的90例患者(男42例,女48例)。年齡16~35歲,平均(21.5±3.2)歲,病程1~20個月,所有患者按《中西醫(yī)臨床皮膚病學》中痤瘡的診療標準確診,入選病例的病情程度符合PillsburyⅠ~Ⅱ度。無明顯肝腎功能異常,非哺乳期及孕婦。按就診先后順序隨機分為兩組。治療組45例:男20例,女25例;平均年齡(20.5±3.6)歲;對照組男22例,女23例;平均年齡(20.5±3.2)歲,兩組患者在年齡、病情等方面,經統(tǒng)計學處理差異無統(tǒng)計學意義(P>0.05),具有可比性。
1.2 診斷標準
參照《皮膚性病學》中痤瘡的診斷標準:該病好發(fā)于顏面或胸背部,對稱分布,可形成黑頭粉刺,丘疹、膿皰、結節(jié)、囊腫等損傷。多發(fā)于青年男女,常伴皮脂滲出[4]。臨床多采用Pillsbury分類法將痤瘡分為4級 (該文著重Ⅰ~Ⅱ度)Ⅰ度(輕度).表現為黑頭粉刺,散發(fā)或多發(fā),散發(fā)性炎癥性丘疹;Ⅱ度(中度)表現在除有輕度表現外,還有深在性丘疹。中醫(yī)辯證標準:肺熱血熱型表現為皮損以紅色丘疹為主,可有膿皰、紅色結節(jié),患處焮熱疼痛,顏面潮紅,舌質紅,苔薄黃,脈細數或弦數等。
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